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Please find information on Turkesterone and where to purchase this in bulk! Studies for this are fairly rare. We will update when new studies come available.
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Synthesis and biological activities of turkesterone 11α-acyl derivatives
Turkesterone is a phytoecdysteroid possessing an 11α-hydroxyl group. It is an analogue of the insect steroid hormone 20-hydroxyecdysone. Previous ecdysteroid QSAR and molecular modelling studies predicted that the cavity of the ligand binding domain of the ecdysteroid receptor would possess space in the vicinity of C-11/C-12 of the ecdysteroid. We report the regioselective synthesis of a series of turkesterone 11α-acyl derivatives in order to explore this possibility. The structures of the analogues have been unambiguously determined by spectroscopic means (NMR and low-resolution mass spectrometry). Purity was verified by HPLC. Biological activities have been determined in Drosophila melanogaster BII cell-based bioassay for ecdysteroid agonists and in an in vitro radioligand-displacement assay using bacterially-expressed D. melanogaster EcR/USP receptor proteins. The 11α-acyl derivatives do retain a significant amount of biological activity relative to the parent ecdysteroid. Further, although activity initially drops with the extension of the acyl chain length (C2 to C4), it then increases (C6 to C10), before decreasing again (C14 and C20). The implications of these findings for the interaction of ecdysteroids with the ecdysteroid receptor and potential applications in the generation of affinity-labelled and fluorescently-tagged ecdysteroids are discussed.
Abbreviation:
CoMFA comparative molecular field analysis
DCM dichloromethane
DMF dimethylformamide
DMP 2,2-dimethoxypropane
4D-QSAR 4-dimensional quantitative structure-activity relationship
EcR ecdysteroid receptor
EcRE ecdysteroid response element
HPLC high-performance liquid chromatography
LBD ligand-binding domain
NMR nuclear magnetic resonance
ponA ponasterone A
QSAR quantitative structure-activity relationship
RXR retinoid X receptor
SAR structure-activity relationship
SPE solid-phase extraction
THF tetrahydrofuran
TLC thin-layer chromatography
p-TsOH para-toluenesulphonic acid
USP ultraspiracle
UV-VIS ultraviolet-visible



Keywords: steroid, ecdysteroid, 20-hydroxecdysone, QSAR, steroid hormone receptor

J Insect Sci. 2003; 3: 6.
Published online 2003 February 24. PMCID: PMC524646

Copyright © 2003. Open access; copyright is maintained by the authors.

Effect of turkesterone and nerobol on the activity of the protein synthesizing system of mouse liver][Article in Russian]
Syrov VN, Kurmukov AG, Sakhibov AD.
Protein biosynthesis was stimulated in liver tissue in vivo and in vitro after administration into mice of either phytoecdizone of turkesterone (0.5 mg/100 g) or of anabolic steroid compound nerobole (1 mg/100 g). Stimulation of protein biosynthesis was due to an increase in functional activity of polyribosomes and to elevation in the synthesis of protein molecules. Actinomycin D, which inhibited the stimulation of protein biosynthesis in liver tissue of mice treated with nerobole, did not affect the phenomenon in mice treated with turkesterone.

PMID: 685188 [PubMed - indexed for MEDLINE]

Phytoecdysteroids and anabolic-androgenic steroids--structure and effects on humans.


Curr Med Chem. 2008;15(1):75-91.

Báthori M, Tóth N, Hunyadi A, Márki A, Zádor E.
Department of Pharmacognosy, University of Szeged, H-6720 Szeged, Eötvös utca 6., Hungary. Bathori@pharma.szote.u-szeged.hu

Phytoecdysteroids are structural analogs of the insect molting hormone ecdysone. Plants comprise rich sources of ecdysteroids in high concentration and with broad structural diversity. Ecdysteroids have a number of proven beneficial effects on mammals but the hormonal effects of ecdysteroids have been proven only in arthropods. Their structures are somewhat similar to those of the vertebrate steroid hormones but there are several structural differences between the two steroid groups. Despite of these essential structural differences, ecdysteroids exert numerous effects in vertebrates that are similar to those of vertebrate hormonal steroids, and they may serve as effective anabolic, hepatoprotective, immunoprotective, antioxidant and hypoglycemic agents. Ecdysteroids do not bind to the cytosolic steroid receptors, instead, they are likely to influence signal transduction pathways, like the anabolic steroids, possibly via membrane bound receptors. The application of phytoecdysteroids is a promising alternative to the use of anabolic-androgenic steroids because of the apparent lack of adverse effects. The prospective use of phytoecdysteroids may extend to treatments of pathological conditions where anabolic steroids are routinely applied. One of the most cited aspects of phytoecdysteroid application (on the Internet) is the increase of muscle size. However in this field too stringent research is needed as an adequate cytological explanation is not yet available for the anabolic. This paper reports on the most important structural differences between androgenic hormones, their synthetic analogs and ecdysteroids. The anabolic/hormonal effects and the possible mechanisms of action of these compounds are also discussed as concerns the skeletal muscle.